Animal Lectins

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Animal lectins: potential receptors for ginseng polysaccharides

Panax ginseng Meyer, belonging to the genus Panax of the family Araliaceae, is known for its human immune system-related effects, such as immune-boosting effects. Ginseng polysaccharides (GPs) are the responsible ingredient of ginseng in immunomodulation, and are classified as acidic and neutral GPs. Although GPs participate in various immune reactions including the stimulation of immune cells ...

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Animal lectins as cell adhesion molecules.

Protein-carbohydrate interaction is exploited in cell adhesion mechanisms besides the recognition of peptide motifs. The sugar code thus significantly contributes to the intriguing specificity of cellular selection of binding partners. Focusing on two classes of lectins (selectins and galectins), it is evident that their functionality for mediation of adhesive contacts is becoming increasingly ...

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Insights into animal and plant lectins with antimicrobial activities.

Lectins are multivalent proteins with the ability to recognize and bind diverse carbohydrate structures. The glyco -binding and diverse molecular structures observed in these protein classes make them a large and heterogeneous group with a wide range of biological activities in microorganisms, animals and plants. Lectins from plants and animals are commonly used in direct defense against pathog...

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Characterization of VIP36, an animal lectin homologous to leguminous lectins.

VIP36 was isolated from MDCK cells as a component of glycolipid-enriched detergent-insoluble complexes. The protein is localized to the Golgi apparatus and the cell surface, and belongs to a new family of legume lectin homologues in the animal secretory pathway that might be involved in the trafficking of glycoproteins, glycolipids or both. Here we show that VIP36 is N-glycosylated and expresse...

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Topography of binding sites of animal lectins: ligands’ view

Synthetic and semisynthetic carbohydrates were used to probe sugar combining sites of animal lectins. For example, using derivatives of monosaccharides, it was determined that the 3-OH and 4-OH groups are absolutely essential and the 6-OH group was dispensable €or both mammalian and chicken hepatic lectins. When the glycosyl units are clustered into a dior tri-branched structure, the binding af...

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ژورنال

عنوان ژورنال: European Journal of Biochemistry

سال: 1997

ISSN: 0014-2956,1432-1033

DOI: 10.1111/j.1432-1033.1997.t01-1-00543.x